Guanylic acid (5'-GMP) - CAS:85-32-5

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Guanylic acid (5'-GMP) (Synonyms:鸟苷酸;鸟嘌呤核苷酸; 5'-GMP; 5'-guanosine monophosphate)

目录号 : KG10119 CAS No. : 85-32-5 纯度 : 98%

Data Sheet SDS 产品使用指南

Guanylic acid is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

规格	价格	是否有货	数量
100mg		In-stock	立即试用

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Guanylic acid (5'-GMP) In-stock
JNJ-55511118 In-stock

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生物活性

Guanylic acid (5'-GMP) is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. Guanylic acid (5'-GMP) regulates the expression of genes related to fatty acid metabolism. Guanylic acid (5'-GMP) is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. Guanylic acid (5'-GMP) also causes neuronal cell death at high concentrations.

IC₅₀&Target

Human Endogenous Metabolite

体外研究

Guanylic acid (5'-GMP) (50-500 μM, 48 h) It can regulate the expression of genes involved in fatty acid metabolism, affect the fatty acid composition in rainbow trout (Oncorhynchus mykiss) liver cells, and regulate fatty acid metabolism.

Cell Viability Assay

Cell Line:	Oncorhynchus mykiss hepatocytes
Concentration:	50-500 μM
Incubation Time:	12-48 hours
Result:	Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1. Downregulated the expression of pparα.

体内研究

Guanylic acid (5'-GMP) (10-150 mg/kg, ip, single dose) has shown anti anxiety effects in Wistar rat models.

Animal Model:	Wistar rats models
Dosage:	10-150 mg/kg
Administration:	ip, single dose
Result:	Increased the time rats spent in the light zone in the light-dark box test. Increased the time rats spent in the open arms in the elevated plus maze test.

分子式

C₁₀H₁₄N₅O₈P

分子量

363.22

CAS号

85-32-5

中文名称

鸟苷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H2O : 83.33 mg/mL (229.42 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7532 mL	13.7658 mL	27.5315 mL
5 mM	0.5506 mL	2.7532 mL	5.5063 mL
10 mM	0.2753 mL	1.3766 mL	2.7532 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

SDS

产品使用指南

Almeida RF, et al. Systemic administration of GMP induces anxiolytic-like behavior in rats. Pharmacol Biochem Behav. 2010 Sep;96(3):306-11.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器