GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
IC50&Target
TBK1
6.8 (pIC50)
体外研究
GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING.
分子式
C17H17BrF3N7O2S
分子量
520.33
CAS号
2361659-62-1
运输条件
Room temperature in continental US; may vary elsewhere.