Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues.
体外研究
The IC50 for Lats-IN-1 increases with the ATP concentration.
Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM.
Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation.
Cell Proliferation Assay
Cell Line:
MCF 10A cells
Concentration:
10 μM
Incubation Time:
24 hours
Result:
Decreased the phosphorylation of Yap at residue S127.
分子式
C18H14N4Os
分子量
334.39
CAS号
1424635-83-5
运输条件
Room temperature in continental US; may vary elsewhere.