S0859 is a selective, high-affinity generic Na/HCO3 transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
IC50&Target
NBC
体外研究
Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
分子式
C29H24ClN3O3S
分子量
530.04
CAS号
1019331-10-2
运输条件
Room temperature in continental US; may vary elsewhere.