2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation.
IC50&Target
P2Y12
体外研究
2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets.
2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets.
分子量
595.69
CAS号
1227193-98-7
运输条件
Room temperature in continental US; may vary elsewhere.