(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity.
体外研究
(3R,4R)-A2-32-01 inhibits hemolysis with an ED50 of 15 nmol on blood agar plates.
(3R,4R)-A2-32-01 exhibits EC50s of 50 μM and 75 μM in dropping metabolic activity of NIH3T3 fibroblasts and HaCat keratinocytes, respectively.
分子式
C19H27NO2
分子量
301.42
CAS号
1359752-95-6
运输条件
Room temperature in continental US; may vary elsewhere.