YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
IC50&Target
IC50: 6.56 nM/1.77 nM/20.5 nM (SIK1/2/3).
体外研究
YKL 06-061 yields a dose-dependent increase in MITF mRNA expression.
RT-PCR
Cell Line:
UACC62 human melanoma cells, and UACC257 human melanoma cells.
Concentration:
0-4 μM (UACC62); 0-16 μM (UACC257).
Incubation Time:
3 hours.
Result:
Yielded a dose-dependent increase in MITF mRNA expression.
分子式
C30H37N7O2
分子量
527.66
CAS号
2172617-15-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:
DMSO : 62.5 mg/mL (118.45 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
1.8952 mL
9.4758 mL
18.9516 mL
5 mM
0.3790 mL
1.8952 mL
3.7903 mL
10 mM
0.1895 mL
0.9476 mL
1.8952 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: