GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
体外研究
GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells.
分子式
C16H16F3N3O5S
分子量
419.38
CAS号
2055015-61-5
运输条件
Room temperature in continental US; may vary elsewhere.