AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action.
IC50&Target
hCB1-R
7.93 (pKi)
hCB2-R
9.06 (pKi)
体外研究
AZD1940 binds with high affinity to human, rat and mouse CB1 and CB2 receptors and displays full agonism at both receptors in all three species.
体内研究
When given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain.
For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates.
分子式
C20H29F2N3O2S
分子量
413.52
CAS号
881413-29-2
运输条件
Room temperature in continental US; may vary elsewhere.