ABT-418 hydrochloride - CAS:147388-83-8

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ABT-418 hydrochloride

目录号 : KM6336 CAS No. : 147388-83-8 纯度 : 98%

Data Sheet 产品使用指南

ABT-418 hydrochloride 是一种高效、选择性的 nAChRs 激动剂，具有增强认知和抗焦虑的作用。ABT-418 hydrochloride 激活胆碱能通道，可用于阿尔茨海默病的研究。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

体内研究

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.

分子式

C₉H₁₅ClN₂O

分子量

202.68

CAS号

147388-83-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 11.9 mg/mL (58.71 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.9339 mL	24.6694 mL	49.3389 mL
5 mM	0.9868 mL	4.9339 mL	9.8678 mL
10 mM	0.4934 mL	2.4669 mL	4.9339 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%