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Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC₅₀ of 6 nM and a K_i of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC₅₀ value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin.

In vitro, Lintitript (SR 27897) is a competitive antagonist of cholecystokinin (CCK)-stimulated amylase release in isolated rat pancreatic acini (pA₂ = 7.50) and of CCK-induced guinea pig gall bladder contractions (pA₂ = 9.57).
Lintitript produces concentration dependent inhibition of [I]CCK binding to CCK1 receptor sites in the rat pancreas (IC₅₀ value of 0.58 nM) and also to CCK 2 sites in the guinea pig cortex (IC₂ value of 479 nM). Lintitript inhibits [I]gastrin binding to gastrin receptors. Lintitript (0.5 nM) increases the dissociation constant of CCK for the CCK A receptor (K_d = 1.8 to 7.2 nM) without modifying the maximum number of receptors (B_max = 1800 to 1770 fmol/mg).

Lintitript (SR 27897; 1 mg/kg, i.v.) completely reverses the CCK-induced amylase secretion. Lintitript also inhibits CCK-induced gastric and gallbladder emptying in mice (ED₅₀s = 3 and 72 μg/kg, respectively). Lintitript is also very active (ED₅₀ = 27 μg/kg p.o.) in the gall bladder emptying protocol with egg yolk as an inducer of endogenous CCK release.

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