PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂，IC50 值为0.28 μM；也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性，IC50 值为 1.05 μM。
| 生物活性 |
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. |
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| 体外研究 |
The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM). |
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| 分子式 |
C19H26O3
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| 分子量 |
302.41
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| CAS号 |
102271-49-8
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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