MJ15
(Synonyms:N-(3-氨基甲基-吡啶)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-羧酰胺)
目录号 : KCM15867
CAS No. : 944154-76-1
纯度 : ≥98%
MJ15 is a potent antagonist of the cannabinoid (CB) receptor CB (IC = 118.9 pM; K = 27.2 pM for rat CB1). It is selective for CB over CB, exhibiting only 46% inhibition of CB at a concentration of 10 μM. MJ15 reverses (+)-WIN 55,212-2 inhibition of forskolin-induced cAMP accumulation in a dose-dependent manner in CHO cells expressing human CB MJ15 (40 mg/kg) reduces food intake and body weight gain in a rat model of diet-induced obesity. It also reduces body weight gain and white adipose accumulation in a mouse model of early onset diet-induced obesity.
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| 分子式 |
C23H17Cl3N4O
|
| 分子量 |
471.8
|
| CAS号 |
944154-76-1
|
| 中文名称 |
MJ 15
|
| 储存方式 |
-20°C
|
客服小K 
客服小K
Data Sheet
