Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.
体外研究
Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways.
Western Blot Analysis
Cell Line:
Human astrocytes (HA) cells
Concentration:
30 μM
Incubation Time:
6 hours
Result:
Decreased p-STAT3,p-MET expression.
分子式
C20H15F3N8
分子量
424.38
CAS号
1440964-89-5
运输条件
Room temperature in continental US; may vary elsewhere.