ABP 688
目录号 : KCM15770
CAS No. : 924298-51-1
纯度 : ≥98%
ABP 688 is a non-competitive antagonist of metabotropic glutamate receptor 5 (mGluR5; K = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors). It is selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 μM. ABP 688 inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (ICs = 2.4 and 2.3 nM, respectively). Radiolabeled forms of ABP 688 have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents.
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| 分子式 |
C15H16N2O
|
| 分子量 |
240.30042
|
| CAS号 |
924298-51-1
|
| 中文名称 |
ABP688
|
| 储存方式 |
-20°C
|
客服小K 
客服小K
Data Sheet
