CB-25 is a stable analog of Δ-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB) and peripheral cannabinoid (CB) receptors with K values of 5.2 and 13 nM, respectively. CB-25 behaves as an inverse agonist for the CB receptor as assessed in a cyclic AMP (cAMP) functional assay.