AAT-008
目录号 : KCM15416 CAS No. : 847727-81-5 纯度 : ≥98%
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E (PGE) receptor subtype 4 (EP; IC = 16.3 nM in a human EP functional assay). It is selective for EP with IC values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP, EP, EP, and EP, respectively. AAT-008 has potent binding affinity for human, rat, and dog EP (Ks = 0.97, 6.1, and 38 nM, respectively) and suppresses PGE-induced elevation of intracellular cAMP with an antagonistic potency (pA) of 1.1 nM in vitro. Oral administration of AAT-008 reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner.
规格 价格 是否有货 数量
1mg
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5mg
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10mg
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25mg
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Other Forms of Rapamycin:

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分子式
C21H16ClFN2O4
分子量
414.8
CAS号
847727-81-5
中文名称
4-[(1S)-1-[[[5-chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-benzoicacid
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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