3,5-Dinitrocatechol (Synonyms:3,5-二硝兒茶酚;3,5-二硝基儿茶酚;3,5-二硝基邻苯二酚;恩他卡朋EP杂质E;恩他卡朋杂质E;恩他卡朋杂质E(EP) 标准品;3,5-二硝茶酚)
目录号 : KCM15166 CAS No. : 7659-29-2 纯度 : ≥98%
3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC = 12 nM). It is selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (ICs = >14 μM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA and carbidopa , reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the β-adrenergic receptor antagonist propranolol .
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分子式
C6H4N2O6
分子量
200.10584
CAS号
7659-29-2
中文名称
3,5-二硝兒茶酚
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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