CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC = 2.3 μM). It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.