Darinaparsin
目录号 : KCM14882 CAS No. : 69819-86-9 纯度 : ≥95%
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (ICs = 5-10 µM) and patient-derived primary prostate cancer cells (ICs = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (ICs = 2.7 and 1.3 µM, respectively). It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 µM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.
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1mg
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5mg
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10mg
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25mg
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Other Forms of Rapamycin:

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分子式
C12H22AsN3O6S
分子量
411.3
CAS号
69819-86-9
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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