ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
IC50&Target
HDAC1
7 nM (IC50)
HDAC2
18 nM (IC50)
HDAC3
1300 nM (IC50)
体外研究
ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors.
分子式
C24H23N5Os
分子量
429.54
CAS号
1609389-52-7
运输条件
Room temperature in continental US; may vary elsewhere.