7α-hydroxy Dehydroepiandrosterone (7α-hydroxy DHEA) is an active metabolite of the endogenous steroid hormone dehydroepiandrosterone . 7α-hydroxy DHEA is formed from dehydroepiandrosterone via 7-hydroxylation by cytochrome P450s (CYPs). It increases antigen-induced production of anti-tetanus toxoid and anti-pertussis antigen IgGs in co-cultures of human tonsil-derived B and T cells when used at a concentration of 1 µM. 7α-hydroxy DHEA (6.25 mg/kg) increases serum concentrations of anti-lysozyme IgG in mice.
7α-hydroxy Dehydroepiandrosterone is a 7α-hydroxylated metabolite of DHEA, catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma.
分子式
C19H28O3
分子量
304.42
CAS号
53-00-9
中文名称
7a-羟基去氢表雄酮;7α-羟基去氢表雄酮;7α-羟基脱氢表雄酮标准品;7-羟基-去氢表雄酮
运输条件
Room temperature in continental US; may vary elsewhere.