Prenylamine (Synonyms:普尼拉明;5-氨基-1-(3,5-二氯-4-(4-氯苯甲酰基)苄基)-1H-1,2,3-三氮唑-4-甲酰胺;异戊二烯基胺)
目录号 : KCM13669 CAS No. : 390-64-7 纯度 : ≥98%
Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a K value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.
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5mg
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10mg
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50mg
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100mg
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分子式
C24H27N
分子量
329.47792
CAS号
390-64-7
中文名称
普尼拉明
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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