13(S)-HODE - CAS:29623-28-7

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13(S)-HODE (Synonyms:13(s)-羟基-9z,11e-十八二烯酸;(S)-Coriolic acid)

目录号 : KCM13186 CAS No. : 29623-28-7 纯度 : ≥98%

Data Sheet 产品使用指南

13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM, and down regulates the expression of the IRGpIIb/IIIa receptor.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock
250μg		In-stock

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生物活性

13(S)-HODE, the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. 13(S)-HODE is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. 13(S)-HODE induces mitochondrial dysfunction and airway epithelial injury[1][2].

体外研究

13(S)-HODE (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium[2].

13(S)-HODE (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. 13(S)-HODE increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. 13(S)-HODE also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation.

体内研究

13(S)-HODE (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.

Animal Model:	BALB/c mice (6-8 weeks)
Dosage:	0-0.6 mg per mouse
Administration:	Intranasally once a day for 3 consecutive days
Result:	BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.

分子式

C₁₈H₃₂O₃

分子量

296.44

CAS号

29623-28-7

中文名称

13(s)-羟基-9z,11e-十八二烯酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

[1]. Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349.

[2]. Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131(3):604-612.

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