8-Bromo-cGMP sodium - CAS:51116-01-9

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8-Bromo-cGMP sodium

目录号 : KM5777 CAS No. : 51116-01-9 纯度 : 98%

Data Sheet 产品使用指南

8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物，是一种 PKG 激活剂。8-Bromo-cGMP sodium 可显着抑制 Ca²⁺ 宏观电流并损害高 K⁺ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca macroscopic currents and impairs insulin release stimulated with high K. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses.

体外研究

8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently.
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.

Cell Viability Assay

Cell Line:	LLC-PK1 cells (ATCC CL 101)
Concentration:	1-100 μM
Incubation Time:	8 hours
Result:	Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%.

Western Blot Analysis

Cell Line:	LLC-PK1 cells (ATCC CL 101)
Concentration:	1-100 μM
Incubation Time:	16 hours
Result:	Induced the synthesis of HO-1 protein in a concentration-dependent fashion.

体内研究

8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).

分子式

C₁₀H₁₀N₅O₇Pbr-^.Na+

分子量

446.08

CAS号

51116-01-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL (224.18 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2418 mL	11.2088 mL	22.4175 mL
5 mM	0.4484 mL	2.2418 mL	4.4835 mL
10 mM	0.2242 mL	1.1209 mL	2.2418 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%