UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
体外研究
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
体内研究
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.
分子式
C14H16ClN5O4S
分子量
385.83
CAS号
256477-09-5
运输条件
Room temperature in continental US; may vary elsewhere.