1,3-PBIT is a potent inhibitor of iNOS with a K of 47 nM compared to K values for eNOS and nNOS are 9 and 0.25 µM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
1,3-PBIT (dihydrobromide) is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 μM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
分子式
C12H18N4S2.2HBr
分子量
444.25
CAS号
200716-66-1
运输条件
Room temperature in continental US; may vary elsewhere.