Butabindide (oxalate) - CAS:185213-03-0

您当前的位置：

Butabindide (oxalate) (Synonyms:UCL-1397 oxalate)

目录号 : KCM12174 CAS No. : 185213-03-0 纯度 : ≥98%

Data Sheet 产品使用指南

Butabindide is a potent inhibitor of cholecystokinin-inactivating peptidase/tripeptidyl peptidase 2 (CCK-inactivating peptidase/TPP-2; K = 7 nM). It is selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Ks = >1 μM) as well as CCK receptors (Ks = >0.1 mM). Butabindide (0.1-100 μM) increases levels of CCK octapeptide in depolarized rat cerebral cortex slices. In vivo, butabindide inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (IDs = 1.1 and 6.8 mg/kg, respectively). It also enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Galegenimab In-stock
Nonacog alfa In-stock
Cathepsin Inhibitor 3 In-stock
α-Methyl-DL-aspartic acid In-stock
MeO-Suc-Arg-Pro-Tyr-pNA In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Butabindide (oxalate) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide (oxalate) inhibits TPP II to protect CCK-8 against inactivation.

IC₅₀&Target

IC50: 7 nM (TPP II) and 10 μM (TPP I)

体外研究

Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) oxalate inhibits TPP II activity in the meninges.

体内研究

Butabindide (UCL-1397; 10 mg/kg; intravenous injection; Oxalate inhibits the breakdown of CCK-8 in the gastrointestinal tract for 20 minutes and increases satiety in mice.

Animal Model:	Mice (25-30 g)
Dosage:	10 mg/kg
Administration:	Intravenous injection; for 20 minutes
Result:	Reduces food intake and elicits other behavioral concomitants of satiation.

分子式

C₁₇H₂₅N₃O₂^.C₂H₂O₄

分子量

393.43

CAS号

185213-03-0

中文名称

[S-(R*,R*)]-1-(2-氨基-1-氧代丁基)-N-丁基-2,3-二氢-1H-吲哚-2-甲酰胺草酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H2O : 39 mg/mL (99.13 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5417 mL	12.7087 mL	25.4175 mL
5 mM	0.5083 mL	2.5417 mL	5.0835 mL
10 mM	0.2542 mL	1.2709 mL	2.5417 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器