RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC of 0.33 µM and activates PPARγ with an EC of 0.3 µM. It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM. RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM. This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.
RB394 is a potent dual sEH/PPARγ modulator isoform that promotes adipocyte browning and exhibits cardioprotective activity, and can be used to suppress metabolic syndrome.
分子式
C21H22F3NO4
分子量
409.40
CAS号
1830320-32-5
运输条件
Room temperature in continental US; may vary elsewhere.