Arachidonoyl-2'-Fluoroethylamide - CAS:166100-37-4

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Arachidonoyl-2'-Fluoroethylamide (Synonyms:(5Z,8Z,11Z,14Z)-N-(2-氟乙基)-5,8,11,14-二十碳四烯酰胺;2,5-二溴-1,4-苯醌)

目录号 : KCM11890 CAS No. : 166100-37-4 纯度 : ≥98%

Data Sheet 产品使用指南

Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB receptor (Ks = 26.7 and 908 nM for CB and CB, respectively). It also contributes additional selectivity, in that binding to CB is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme.

规格	价格	是否有货
5mg	¥1197.00	In-stock
10mg	¥2268.00	In-stock
50mg	¥9576.00	In-stock
100mg	¥16758.00	In-stock

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Other Forms of Rapamycin:

CB2R/FAAH modulator-3 In-stock
AM-2232 In-stock
Virodhamine In-stock
(±)-Cannabichromene In-stock
Arachidonoyl-2'-Fluoroethylamide In-stock

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生物活性

Arachidonoyl-2'-Fluoroethylamide is an anandamide analog. Arachidonoyl-2'-Fluoroethylamide has the potential for the research of intraocular hypertension.

体内研究

Arachidonoyl-2'-Fluoroethylamide (0.25% (w/v) 25 µl) induced an initial increase followed by a decrease in intraocular pressure (IOP) in rabbits.

Animal Model:

2.6-3.6 kg normotensive pigmented rabbit

Dosage:

25 µl (0.25% (w/v))

Administration:

Unilateral ocular administration

Result:

Induced IOP (intraocular pressure) in the treated eye initially increased and then decreased.

分子式

C₂₂H₃₆FNO

分子量

349.53

CAS号

166100-37-4

中文名称

2,5-二溴-1,4-苯醌

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器