Melperone (hydrochloride) - CAS:1622-79-3

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Melperone (hydrochloride) (Synonyms:盐酸美哌隆)

目录号 : KCM11811 CAS No. : 1622-79-3 纯度 : ≥98%

Data Sheet 产品使用指南

Melperone is an atypical antipsychotic. It binds to α- and α-adrenergic and dopamine D receptors (Ks = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT (K = 102 nM). It is selective for these receptors over histamine H, muscarinic, 5-HT, 5-HT, and 5-HT receptors (Ks = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.

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5g	询价	In-stock

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生物活性

Melperone (hydrochloride) is a butyrophenone with atypical antipsychotic properties. Melperone (hydrochloride) is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone (hydrochloride) has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone (hydrochloride) can be used for the study of schizophrenia, and agitation in the elderly[1].

IC₅₀&Target

5-HT1A Receptor 5-HT1D Receptor 5-HT2A Receptor 5-HT2C Receptor

Human D2 Receptor α1-adrenergic receptor α2-adrenergic receptor CYP2D6

180 nM (Kd) 180 nM (Kd) 150 nM (Kd)

体内研究

Melperone (2 mg/kg/day; drinking water; Replace the water bottle twice a week in a dark place; Hydrochloride can increase the basal extracellular dopamine levels in the rat nucleus accumbens for 21 days, but does not affect the extracellular dopamine levels induced by D-amphetamine [1].

Animal Model:	Male Sprague-Dawley albino rats (180-200 g) was administered subcutaneously with D-Amphetamine sulfate (1.0 mg/kg)^[1]
Dosage:	2 mg/kg/day
Administration:	Drinking water; changed in lightproof drinking bottles twice a week; for 21 days
Result:	Increased basal extracellular DA and enhanced D-Amphetamine-induced DA release in the striatum.

分子式

C₁₆H₂₂FNO^.HCl

分子量

299.81

CAS号

1622-79-3

中文名称

盐酸美哌隆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (166.77 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3354 mL	16.6772 mL	33.3545 mL
5 mM	0.6671 mL	3.3354 mL	6.6709 mL
10 mM	0.3335 mL	1.6677 mL	3.3354 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

[1]. Lurasidone Improves Psychopathology and Cognition in Treatment-Resistant Schizophrenia

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器