Flonicamid - CAS:158062-67-0

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Flonicamid (Synonyms:氟啶虫酰胺; IKI220)

目录号 : KCM11731 CAS No. : 158062-67-0 纯度 : ≥98%

Data Sheet SDS 产品使用指南

Flonicamid is a pyridinecarboxamide insecticide. It inhibits the brown planthopper (N. lugens) inward-rectifying potassium channel K1 (IC = 0.64 µM). Flonicamid (100 µg/ml) inhibits aphid (M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species A. gossypii, R. padi, S. graminum, and L. erysimi (LCs = 0.64, 0.74, 0.78, and 2.01 µg/ml, respectively) and rats (LD = ≥844 mg/kg). Formulations containing flonicamid have been used for the control of pest insects in agriculture.

规格	价格	是否有货	数量
200mg		In-stock
500mg	询价	In-stock

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生物活性

Flonicamid is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent.

体外研究

Flonicamid (0.2-12.5 mg AI L⁻¹; 5 days) can efficiently kill cotton aphids (Aphis gossypii), Rhopalosiphum padi, wheat aphids (Schizaphis graminum), and radish aphids (Lipaphis erysimi) on their respective host plants, with LC₅₀ values ranging from 0.64 to 2.01 mg AI L⁻¹ after 5 days of exposure.

Flonicamid (0.2-12.5 mg AI L^-1; 5 days) can efficiently kill first instar nymphs, wingless adults, and winged adults of peach aphids on Japanese radish leaves, with LC₅₀ values ranging from 0.61 to 0.77 mg AI L^-1 after 5 days of exposure.

Flonicamid can effectively inhibit the inward K⁺current in HEK293 cells transfected with NlKir1, with an IC₅₀ of 0.64 μM.

Flonicamid (0.5-20 μM; 20 min) can inhibit the stable transfection of NLKir1 mediated thallium ion flux in HEK293 cells, with an IC₅₀ of 1.96 μM.

体内研究

Flonicamid (0-57.3 ng/adult mosquito; Local administration in the abdomen; Single dose can inhibit the renal excretion of female Culex pipiens pallens after blood sucking, with an ED₅₀ of 9.50 ng/adult mosquito; It can also cause dose-dependent disability, with an LD₅₀ of 15.38 ng/female mosquito.
Flonicamid exhibits almost identical toxicity to insecticide sensitive and resistant populations of the brown planthopper (Nilaparvata lugens), with an LC₅₀ of 44.64 mg/L for the sensitive strain and no cross resistance with other commonly used insecticides .

Animal Model:	(2-4 day-old blood-fed adult females)
Dosage:	0-57.3 ng/adult
Administration:	topical application to abdomen; single dose
Result:	Inhibited renal excretion in a dose-dependent manner, with an ED₅₀ of 9.50 ng/adult. Caused dose-dependent incapacitation (flightless or dead) at 48 h, with an LD₅₀ of 15.38 ng/female.

分子式

C₉H₆F₃N₃O

分子量

229.16

CAS号

158062-67-0

中文名称

氟啶虫酰胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (436.38 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.3638 mL	21.8188 mL	43.6376 mL
5 mM	0.8728 mL	4.3638 mL	8.7275 mL
10 mM	0.4364 mL	2.1819 mL	4.3638 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% saline

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.91 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO → 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.91 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
3.

请依序添加每种溶剂： 10% DMSO → 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.91 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

纯度： ≥98%

Data Sheet

SDS

产品使用指南

Morita M, et al. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest management science. 2007 Oct;63(10):969-73.

Ren M, et al. Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. Insect biochemistry and molecular biology. 2018 Aug;99:17-26.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器