1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with K values of 7.4 and 16 nM, respectively, compared to a K of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
1,4-PBIT (dihydrobromide) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively.
IC50&Target
iNOS eNOS nNOS
7.6 nM (Ki) 360 nM (Ki) 16 nM (Ki)
分子式
C12H18N4S2.2HBr
分子量
444.2
CAS号
157254-60-9
中文名称
1,4-PB-ITU 二氢溴酸盐
运输条件
Room temperature in continental US; may vary elsewhere.