Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro (IC = 383.2 μM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK (Ks = 12, 42, and 43 μM, respectively).
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with Ki values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.
IC50&Target
NK1R
分子式
C24H19N3O2
分子量
381.43
CAS号
157047-96-6
运输条件
Room temperature in continental US; may vary elsewhere.