Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system.
IC50&Target
Gap-junction
体外研究
Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms.
体内研究
Treatment with Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis.
分子式
C20H19NO4FCl
分子量
391.82
CAS号
175013-84-0
中文名称
托那博沙
运输条件
Room temperature in continental US; may vary elsewhere.