C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) - CAS:151057-28-2

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C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) (Synonyms:Sulfo galactosylceramide;N-Nervonoyl Sulfatide; C24:1 Sulfatide)

目录号 : KCM11592 CAS No. : 151057-28-2 纯度 : ≥98%

Data Sheet 产品使用指南

C24:1 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3’-sulfo galactosylceramide in rat cerebellum from seven to 32 days of age when active myelination occurs. It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5. It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay via LMIR5. C24:1 3’-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d in vitro, and increases proliferation in isolated mouse splenocytes. It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 µg. It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

规格	价格	是否有货	数量
1mg		In-stock

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生物活性

C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

分子式

C₄₈H₉₁NO₁₁S

分子量

890.30

CAS号

151057-28-2

中文名称

N-[(1S)-2R-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3E-heptadecen-1-yl]-15Z-tetracosenamide

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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