8-(3-Chlorostyryl)caffeine - CAS:147700-11-6

您当前的位置：

8-(3-Chlorostyryl)caffeine (Synonyms:8-[(E)-2-(3-氯苯基)乙烯基]-1,3,7-三甲基-3,7-二氢-1H-嘌呤-2,6-二酮;(E)-CSC)

目录号 : KCM11515 CAS No. : 147700-11-6 纯度 : ≥98%

Data Sheet 产品使用指南

8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A receptor antagonist (K = 54 nM). It is selective for adenosine A over A receptors (K = 28 µM). CSC reverses locomotor depression induced by the adenosine A agonist APEC in mice (ED = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A receptor levels induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA . It also inhibits monoamine oxidase B (MAO-B; K = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A mice.

规格	价格	是否有货	数量
10 mM * 1 mL in DMSO		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

PF-02575799 In-stock
1-Ethyl-6-aminouracil In-stock
Xanthine amine congener trihydrochloride In-stock
GW-493838 In-stock
CHEMBL241987 In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

8-(3-Chlorostyryl)caffeine is a MAO-B inhibitor and adenosine A_2A receptor antagonist. 8-(3-Chlorostyryl)caffeine inhibits the activity of monoamine oxidase B through a pathway independent of adenosine A_2A receptor antagonism. 8-(3-Chlorostyryl)caffeine can be used in research related to Parkinson's disease.

IC₅₀&Target

A2AR MAO-B

70 nM (Ki)

体外研究

8- (3-Chlorostyryl) caffeine (different inhibitor concentrations; When MMTP was used as a substrate for 15 minutes, MAO-B in baboon liver mitochondria was effectively and competitively inhibited, with a Ki value of 128 nM [1].

8- (3-Chlorostyryl) caffeine (different inhibitor concentrations; When using benzylamine as a substrate for 8 minutes, it can effectively and competitively inhibit monoamine oxidase B (MAO-B) in baboon liver mitochondria, with a Ki value of 148 nM [1].

分子式

C₁₆H₁₅ClN₄O₂

分子量

330.77

CAS号

147700-11-6

中文名称

8-[(E)-2-(3-氯苯基)乙烯基]-1,3,7-三甲基-3,7-二氢-1H-嘌呤-2,6-二酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 8.27 mg/mL (25.00 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0232 mL	15.1162 mL	30.2325 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

[1]. Vlok N, et al. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg Med Chem. 2006;14(10):3512-3521.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器