Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs = 2.0 and >500 µg/ml at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC = 1.58 µg/ml) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC = 2.0 µg/ml for both).