BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor.
体外研究
BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [H]CE-HDL uptake in ldlA[mSR-BI] cells.
BLT-1 has an IC50 of 0.96 μM for the HCV entry in Huh 7.5.1 cells.
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells.
BLT-1 can inhibit SR-BI-dependent selective uptake of [H]CE from [H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) .
分子式
C12H23N3S
分子量
241.40
CAS号
321673-30-7
运输条件
Room temperature in continental US; may vary elsewhere.