Artesunate-d4 (Synonyms:青蒿酯-d4)
目录号 : KCM11019 CAS No. : 1316753-15-7 纯度 : 98%
Artesunate-d is intended for use as an internal standard for the quantification of artesunate by GC- or LC-MS. Artesunate is a derivative of artemisinin that is active against P. falciparum in vitro (IC = 1.28 nM). It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC value of 2.05 nM. Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day. It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin in rats. Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.
规格 价格 是否有货 数量
500μg
In-stock
1mg
In-stock

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生物活性

Artesunate-d4 is deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

分子式
C19H24D4O8
分子量
388.5
CAS号
1316753-15-7
中文名称
青蒿酯-d4;青蒿琥酯-d4;二氢青蒿素-12-α-丁二酸单酯-d4
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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