MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM).
MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC50 of 69 nM.
MLT-748 (2 µM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1 patient immortalized B cells.
Western Blot Analysis
Cell Line:
MALT1 patient immortalized B cells
Concentration:
2 µM
Incubation Time:
24 hours
Result:
Increased NF-κB signaling phosphorylation of both p65 and IκBα as early as 5 min after stimulation with PMA and ionomycin.
分子式
C19H19Cl2N9O3
分子量
492.32
CAS号
1832578-30-9
运输条件
Room temperature in continental US; may vary elsewhere.