5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B (LTB) to 6-trans LTB in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE is not a substrate for soybean lipoxygenase. The biological activity of 5(S),6(R)-11-trans DiHETE has not been reported.
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists.
分子式
C20H32O4
分子量
336.5
CAS号
129263-59-8
中文名称
(5S,6R,7E,9E,11E,14Z)-5,6-Dihydroxy-7,9,11,14-icosatetraenoic aci d
运输条件
Room temperature in continental US; may vary elsewhere.