3'-Sialyllactose (sodium salt) - CAS:128596-80-5

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3'-Sialyllactose (sodium salt) (Synonyms:3'-唾液乳糖钠盐;3'-SL sodium)

目录号 : KCM10929 CAS No. : 128596-80-5 纯度 : ≥98%

Data Sheet SDS 产品使用指南

3'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 3 position. It is an abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum. 3'-Sialyllactose avidly binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus. In some cases, binding of 3’-sialyllactose to viral proteins alters viral infectivity. 3'-Sialyllactose also alters Helicobacter activity and impacts bacterial colonization of gut.

规格	价格	是否有货	数量
10 mM * 1 mL in Water		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock

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生物活性

3'-Sialyllactose (sodium salt) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose (sodium salt) is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2].

体外研究

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[2].
3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[2].

Western Blot Analysis

Cell Line:

Chondrocytes

Concentration:

0, 50, 100 and 250 μM

Incubation Time:

24-36 hours

Result:

Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

体内研究

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice[2].
3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[2].
3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[2].

Animal Model:	8-week-old male C57BL/6 mice with medial meniscus surgery
Dosage:	10, 50 and 100 mg/kg
Administration:	Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result:	Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

分子式

C₂₃H₃₈NO₁₉^.Na

分子量

655.5

CAS号

128596-80-5

中文名称

3'-唾液乳糖钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H2O : 233.33 mg/mL (355.94 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5255 mL	7.6274 mL	15.2548 mL
5 mM	0.3051 mL	1.5255 mL	3.0510 mL
10 mM	0.1525 mL	0.7627 mL	1.5255 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

SDS

产品使用指南

[1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66.

[2]. Kim D, et al. Toxicological evaluation of 3'-sialyllactose sodium salt. Regul Toxicol Pharmacol. 2018 Apr;94:83-90.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器