Termitomycamide B
目录号 : KCM10844 CAS No. : 1254277-89-8 纯度 : ≥97%
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson’s, Alzheimer’s, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.
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5mg
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10mg
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25mg
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50mg
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生物活性

Termitomycamide B is a neuroprotective agent that can be obtained from Termitomyces titanicus. Termitomycamide B effectively inhibits endoplasmic reticulum stress-dependent cell death. Termitomycamide B can be used in the study of neurodegenerative diseases[1].

体外研究

Termitomycamide B has significant protective activity against endoplasmic reticulum (ER) stress-induced cell death, and is dose-dependent [1].

分子式
C28H40N2O2
分子量
436.6
CAS号
1254277-89-8
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month

[1]. Choi JH, et al. Termitomycamides A to E, fatty acid amides isolated from the mushroom Termitomyces titanicus, suppress endoplasmic reticulum stress. Org Lett. 2010 Nov 5;12(21):5012-5. 

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