VU0364572 (trifluoroacetate salt) - CAS:1240514-89-9

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VU0364572 (trifluoroacetate salt) (Synonyms:(3R)-3-[(2-甲基苯甲酰)氨基]-[1,4'-联哌啶]-1'-羧酸乙酯 2,2,2-三氟乙酸盐)

目录号 : KCM10787 CAS No. : 1240514-89-9 纯度 : ≥98%

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VU0364572 is a potent and selective agonist of the muscarinic acetylcholine receptor 1 (M; EC = 0.2 mM compared to >10 mM for M-M). It induces concentration-dependent increases in Ca mobilization and ERK1/2 phosphorylation in CHO cells transfected with the human M receptor (ECs = 0.89 and 10 mM, respectively) with no effect on β-arrestin recruitment. VU0364572 also improves hippocampal-dependent spatial learning and localization abilities and acquistion of contextual fear learning but cannot reverse amphetamine-induced hyperlocomotion in rats. This suggests therapeutic potential of VU0364572 for the treatment of Alzheimer's disease but not psychosis.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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2-thio-Acetyl MAGE In-stock
Arachidonic Acid-d₈ In-stock
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AB-FUBINACA (CRM) In-stock
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分子式	C₂₁H₃₁N₃O₃^.Cf₃CoOH
分子量	373.5
CAS号	1240514-89-9
中文名称	VU0364572 TFA Salt
储存方式	-20°C

纯度： ≥98%

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