HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent.
IC50&Target
IC50: 1.0 μmol/L (HCV NS3/4A protease).
体外研究
HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others.
Cell Viability Assay.
Cell Line:
HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others.
Concentration:
0-10 μmol/L.
Incubation Time:
72 h.
Result:
Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.
分子式
C12H16N4O
分子量
232.28
CAS号
1009734-33-1
运输条件
Room temperature in continental US; may vary elsewhere.