AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate TFA 具有抗逆转录病毒的活性，并抑制 HIV 复制。AZT triphosphate TFA 还可抑制 HBV 的 DNA 聚合酶。AZT triphosphate TFA 可激活线粒体介导的凋亡 (apoptosis) 途径。
| 生物活性 |
AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway. |
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| 体外研究 |
Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts. |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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