ASP-2535 是一种高效、有口服活性、选择性的，脑渗透性和中心活性的 GlyT1 抑制剂。ASP-2535 能改善精神分裂症和阿尔茨海默病动物模型的认知障碍。
| 生物活性 |
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease. |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro. |
|||||||||
| 体内研究 |
ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice.
|
|||||||||
| 分子式 |
C22H18N6O
|
|||||||||
| 分子量 |
382.42
|
|||||||||
| CAS号 |
374886-51-8
|
|||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
|||||||||
| 储存方式 |
|
纯度： 98%
关注我们
获得KKL MED 最新资讯
客服小K 
客服小K
Data Sheet