Dotinurad is a potent and selective urate reabsorption inhibitor. Dotinurad inhibits urate transporter 1 (URAT1) with an IC50 value of 37.2 nM. Dotinurad acts as a uricosuric agent.
IC50&Target
IC50: 37.2 nM (URAT1)
体外研究
Dotinurad has higher selectivity for urate transporter 1 (URAT1) versus ATP-binding cassette subfamily G member 2 (ABCG2) and organic anion transporter (OAT) 1/3. Dotinurad weakly inhibits ABCG2, OAT1, and OAT3, with IC50 values of 4.16, 4.08, and 1.32 μM, respectively.
体内研究
Dotinurad exhibits low oral bioavailability (2.5 %) and Cmax (415 ng/mL) following oral administration (1.3 mg/kg). Dotinurad also exhibits terminal elimination half-life (T1/2 1.88 h) due to high plasma clearance (24126 mL/h/kg) following oral administration (1.3 mg/kg) in Sprague-Dawley rats.
分子式
C14H9Cl2NO4S
分子量
358.20
CAS号
1285572-51-1
运输条件
Room temperature in continental US; may vary elsewhere.