Rimacalib (SMP 114) is a Ca/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.
体外研究
Rimacalib (SMP-114) improves (by ~40%) Ca-transient potentiation during the 30 s stimulation pause, higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control, n=60/17 cells/mice vs. n=65/17, p<0.05) and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098).
分子式
C22H23FN4O2
分子量
394.44
CAS号
215174-50-8
运输条件
Room temperature in continental US; may vary elsewhere.